Preparation and Characterization of diclofenac enteric microcapsules obtained by Gelling Ionic

Authors

DOI:

https://doi.org/10.5377/universitas.v2i1.1640

Keywords:

Alginate, Ionic gelation, Microcapsules, Diclofenac

Abstract

Diclofenac microcapsules were obtained through ionic gelation of an alginate solution. Parameters such as morphology, particle size distribution, encapsulation efficiency, and in vitro release studies, among others, were determined. The developed technique allowed for the production of a system with micrometric characteristics and good encapsulation efficacy.

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Author Biographies

J.A. Calero-Herrera, National Autonomous University of Nicaragua, León.Nicaragua

Researcher at the Department of Pharmaceutical Technology and Department of Analysis, Faculty of Chemical Sciences.

Y.F. Sánchez, National Autonomous University of Nicaragua, León. Nicaragua

Researcher at the Department of Pharmaceutical Technology and Department of Analysis, Faculty of Chemical Sciences.

R.J. Tórrez-Barrera, National Autonomous University of Nicaragua, León. Nicaragua

Researcher at the Department of Pharmaceutical Technology and Department of Analysis, Faculty of Chemical Sciences.

E. Hernann, National Autonomous University of Nicaragua, León. Nicaragua

Researcher at the Department of Pharmaceutical Technology and Department of Analysis, Faculty of Chemical Sciences.

K. López, National Autonomous University of Nicaragua, León. Nicaragua

Researcher at the Department of Pharmaceutical Technology and Department of Analysis, Faculty of Chemical Sciences.

References

Lamas MC, bregni C, Frías M, Velázquez R. (1998). Hydrogel microspheres for flutamide obtained by múltiple emulsions. S.t.P. Pharma Science; 8(6): 375-378.

Gombotz WR, Wee SF. (1998). Protein release from alginate matrices. Advanced Drug Delivery Reviews; 31: 267-285.https://doi.org/10.1016/S0169-409X(97)00124-5

Vila jato jL. (1997). tecnología Farmacéutica - Aspectos fundamentales de los sistemas farmacéuticos y operaciones básicas, editorial Síntesis, pp. 75-90.

Rodriguez-Llimos AC, Chappetta D, Szeliga Me, Fernández A, bregni C. (2003). Micropartículas de alginato conteniendo paracetamol. A.R.S. Farmaceutica, 44(4): 332-342.

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Published

2008-07-03

How to Cite

Calero Herrera, J. A., Sánchez, Y. F., Tórrez Barrera, R. J., Hernann, E., & Kaitlin. (2008). Preparation and Characterization of diclofenac enteric microcapsules obtained by Gelling Ionic. Universitas (León), 2(1), 27–30. https://doi.org/10.5377/universitas.v2i1.1640

Issue

Vol. 2 No. 1 (2008)

Section

Original Scinetific Articles

License

Copyright (c) 2008 Array

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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